Denver Broncos vs. San Francisco 49ers Prediction, Tips & Odds – September 26, 2022 02:20 CET

Mr. Reddington
September 24, 2022
Denver Broncos vs. San Francisco 49ers Prediction

The most interesting game of the NFL week 3 will be played in Colorado between the Denver Broncos and the San Francisco 49ers.

Denver Broncos

The Denver Broncos won the Super Bowl in February 2016. Peyton Manning retired after that game and everything went downhill for this franchise. Since then, they have never played in the playoffs again and they changed a large number of head coaches and quarterbacks in just six years.

At the end of last season, Vic Fangio was fired. Instead of him, Nathaniel Hackett was hired as new head coach, but it’s already clear that it was not the best choice. Hackett made several disastrous mistakes in first two weeks and doesn’t look like good coaching material. Also, the Broncos signed Russell Wilson, which was one of the biggest moves of the entire NFL offseason. That was supposed to immediately put them in a position to be one of the best teams in AFC, but it doesn’t seem like that will be the case.

If the Broncos don’t make drastic improvements in a short period of time, they won’t make the playoffs again. Impression is that they are the weakest team in their division and difficult games are coming in next period.

San Francisco 49ers

The San Francisco 49ers got back on track last season. For several years, they were the unluckiest team in the entire league as they had a huge number of injuries. As soon as all key players returned, they immediately reached the conference finals where they lost to the Los Angeles Rams.

Their fans had the most complaints against quarterback Jimmy Garoppolo, even though he had a lot of good games in 49ers jersey. Much was expected from young Trey Lance, but he broke his ankle last week and his season is over. That’s maybe not even bad news because Lance has looked much weaker than Garoppolo over the past two weeks. Suddenly, there is a good dose of optimism again and the 49ers could show their best edition in Denver.

Last Sunday, the 49ers destroyed the Seattle Seahawks. Defense is more than good, while Kyle Shanahan’s creativity in offense will never be in question. The 49ers are coming to Colorado in a good mood and with big desire to win.


The last time these two teams played against each other was four years ago when the 49ers won 20:14 in San Francisco.


Darius Philips is injured and won’t play for the Denver Broncos, while several players are questionable including Jerry Jeudy and Pat Surtain. In addition to Trey Lance, Daniel Brunskill won’t play for the San Francisco 49ers. George Kittle is expected to debut this season.

Denver Broncos vs. San Francisco 49ers Prediction

This might be the biggest value of all NFL bets this week. It’s a bit surprising that the 49ers aren’t much bigger favorites based on what we’ve seen so far. It is possible that something clicks with the Broncos and they shine, but if both teams show form from the previous week, the 49ers will triumph easily.

Date and Time: 26.09.2022. 02:20 CET
Pick: San Francisco 49ers to win
Odds: 1.80
Bookmaker: BetUS

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Author Mr. Reddington

We don't know a man who follows more sports than Mr. Reddington. He is one of our most profitable tipsters, who successfully gives free predictions from basketball, football, formula 1, NFL, and many other sports. Privately, when he is not making a profit for our readers, Mr. Reddington loves Italian cuisine and traveling. In our team, he is also known as the person who makes the best carbonara pasta.

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